Usage Note
Narcotraffico is a compound of narcotico (narcotic) + traffico (traffic/trade) and is the standard journalistic and legal term for drug trafficking in Italian. It is invariable in register — no informal synonym is widely used. The related agent noun is narcotrafficante (drug trafficker).
Examples
"Il narcotraffico è un problema globale."
Natural Translation
Drug trafficking is a global problem.

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