Usage Note
Sinceramente can introduce a candid opinion (sinceramente, non lo so, 'honestly, I don't know') or modify a verb (ti ringrazio sinceramente, 'I sincerely thank you'). As a sentence opener it functions like English 'to be honest' or 'frankly', softening a direct statement.
Examples
"Sinceramente, non capisco perché l'abbiano fatto."
Natural Translation
Honestly, I don't understand why they did it.

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